search-compare module version 95.0 (Accelrys)
90
Structured Review
Accelrys
search-compare module version 95.0
Search Compare Module Version 95.0, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/search-compare+module+version+95%2E0/search+compare+module+version+95+0/pm16835370-58-29-32
Average 90 stars, based on 1 article reviews
Search Compare Module Version 95.0, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/search-compare+module+version+95%2E0/search+compare+module+version+95+0/pm16835370-58-29-32
Average 90 stars, based on 1 article reviews
search-compare module version 95.0 - by Bioz Stars,
2026-10
90/100 stars
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other:Article Title: Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells. Article Snippet: Tamoxifen is a selective estrogen receptor modulator (SERM) used for the treatment and prevention of breast cancer.. Tamoxifen has been reported to protect against the progression of coronary artery diseases in human and different atherosclerosis animal models by blocking the appearance of the atheromatous plaque.. However, the molecular mechanism of this effect remains unknown. Article Title: The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors. Article Snippet: We have shown recently that estrogen receptor (ER) ligands share a diphenyl ethane pharmacophore with Sah 58-035 [3-[decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide], a prototypical inhibitor of the acyl-cholesterolacyl-transferase (ACAT), which enabled us to establish that ER ligands were potent inhibitors of ACAT and blocked the formation of foam cells.. In the present study, we have tested whether this structural similarity means that Sah 58-035 is an ER modulator.. We report that Sah 58-035 bound to ER and ER with an IC50 of 2.9 and 3.1 M, respectively. |